May 30, 2016
Updated Dec 2016.
RVHD1 and RVHD2
This article will provide a concise overview of Rabbit Hemorrhagic Viral Disease, its characteristics, locations, testing methods and some of the preventative steps that can be taken.
Rabbit Viral Haemorrhagic Disease 1 is a type of Calicivirus, has been in Europe for many decades or even centuries and affects both wild and domestic rabbits. There are a few different pathogenic strains of the virus but until recently, RVHD1 was thought to be the only type in the UK.
RVHD2 differs in a few key ways as it is unaffected by age and has a longer illness phase with different clinical symptoms. It is also thought to have a lower mortality rate. Little research has been done on RVHD2 and it is highly likely that cases are under reported.
Both viruses are potentially very easily spread and can live in the environment for a long time (RVHD2 up to 200 days in laboratory conditions) Insects, wildlife and scavengers can spread it as well as direct contact with an infected rabbit. Fomites such as bedding, wild plants, shoes and clothing can also carry the virus to new areas. It is currently unknown if biting insects can spread RVHD2.
Due to it being so easily transported, the spread of RVHD can be very quick and strict biosecurity is recommended as well as vaccination.
The current UK vaccine, Nobivac Myxo-RHD offers protection against RVHD1 but is unlikely to offer any for RVHD2 as this virus is antigenically and genetically different from RVHD1. It is recommended that a second vaccination be given to cover RVHD2 and there are a few options:
- Eravac has been licensed in the UK for use in ‘fattening’ rabbits. This is an oil based drug with no research showing the possible long term effects and there is currently no recommended vaccination schedule.
- Cunivak RHD is currently out of stock and Cunipravac can be ordered via a special import certificate however it is only available in large multi dose bottles.
- Filavac RHD K C+V is available to order from most UK wholesalers and is administered annually or 6 monthly (if considered to be a high risk patient or area). It is vital that the rabbits are still vaccinated with the Nobivac Myxo-RHD as the Filavac vaccine does not give any protection against myxomatosis, however standard immunology advice is to leave at least a 2 week gap between the different vaccinations.
It is important to research all options and discuss with your vet / client. The safety and efficacy of using any other vaccine alongside the Nobivac Myxo RHD has not been studied.
It is not recommended to carry out en-mass vaccination clinics as this could potentially increase the risk of disease spread due to the way RVHD is transmitted.
Testing and Reporting
Its important to consider RVHD2 as a differential diagnosis when dealing with a sick rabbit that doesnt seem to respond to treatment and no obvious reason for the illness is found. PCR testing is now available for live rabbits via the Batt Laboratories in Coventry. For sudden deaths, post mortem liver samples can also be sent here or to the Moredun Research Institute.
Wherever possible, please send samples to either laboratory via the methods outlined on their websites. Please also consider reporting all suspicious deaths to the Rabbit Welfare Association and Fund as their Veterinary Advisor is monitoring the spread of this disease.
Good husbandry is paramount and sick rabbits should be barrier nursed. Enhanced cleaning, disinfection and quarantine protocols can be implemented in practice and with owners. Anigene HLD4V is a veterinary grade product that is believed to be effective against RVHD when used at a concentration of 1:50 for soiled conditions.
It is vital to be aware of the risks associated with attending events such as rabbit shows, petting zoos and even rescues. Environmental insect controls should also be in place as it is still unknown if RVHD2 can be spread via insects. Care should also be taken when considering feeding handpicked wild plants.
Keeping Up To Date
There is a great group on Facebook
where people can report suspected and confirmed cases of RVHD1 & RVHD2. This links to a UK map and it also holds a wealth of information and support – I recommend everyone to join.
You can also visit the Rabbit Welfare Association’s website as they will always have the most up to date and factually correct info.
Lastly, Rabbit Specialist Vet Francis Harcourt Brown (retired) has information about the disease on her website.
Be wary of other reports and anecdotal stories doing the rounds as they may not be factually accurate. Also, please contact your own vet asap so they are fully aware of the new RVHD2 strain and that they are stocking and advertising the new vaccine to help fight this. We need owners to insist all their vets order in the vaccine to get as many rabbits as possible protected against this fatal disease.
Please know how to keep your rabbits safe and spread the word!
January 12, 2016
RVHD and Myxomatosis are diseases found throughout the UK and can be fatal to un-vaccinated rabbits. Both outdoor AND indoor rabbits are at risk. RVHD in particular is highly infectious and contagious. It is an air borne virus that can be spread by direct and indirect contact with infected rabbits, food bowls, hutches and even the soles of your shoes. For example – if you, your dog or cat has walked on ground where a VHD infected rabbit has been, you can carry it on your clothes or shoes, your other pets can carry it on fur or feet. The virus can survive in the environment for a long time and can survive cold temperatures far better than you might expect.
“As you may know, over the past year there has been an increasing concern regarding RVHD “new variant 2” becoming a cause of deaths in several outbreaks in the UK. Whilst it has been noted in the UK in research papers (Westcott and Choudhury) for at least 2 years, it has clearly become a significant clinical entity in the past few months.
We (RWAF) have now successfully established an SIC (Special Import Certificate) for a suitable EU member state vaccine, Cunivak RHD, and placed an order for a small number of vaccines to establish an ordering system into the UK.
Vets can order their own supplies from VMD. If they require any further information, they should contact the RWAF at [email protected] and we will pass on any veterinary queries to our vet, Mr Saunders, but they should be aware that he may be dealing with a high volume of email. A more detailed explanation of the above should be available in Vet Times and Vet Record soon.”
What This Means For Owners.
Firstly – please note that NO emails from owners about this topic will be passed to Dr Saunders. he will be dealing with Vet emails only due to the high volume of contact.
So for owners – this means you will need to ask your vets to order in the new vaccine which will take a few weeks for them to sort out. The new Cunivak vaccine is NOT a replacement for the current combo vaccine and will need to be given AS WELL AS the Nobivak
one. Its important to note that these vaccines CANNOT be given at the same time and need at least a 2 week gap between them.
In total, your rabbit will now require 2 vaccinations (comprising of 3 injections) per year:
1) Nobivak combo – Just one injection covers them for myxomatosis and RHVD1.
2) Cunivak RHVD – 2 injections 3 weeks apart. This covers them against RHVD2.
You need to leave AT LEAST 2 weeks gap between the different types of vaccines. If you can manage to schedule it so that there is a gap of 4-6 months between vaccines then this would mean your rabbit would have a veterinary health check up approx every 6 months. BUT you don’t HAVE to work to this schedule, just make sure there is at least 2 weeks between vaccines.
Please contact your vets and ask them to start the process of ordering in the new Cunivak RHD vaccine. Most vets will not be aware that they can do this as the information has only just been released. But the quicker you contact them, the quicker they can get up to speed and get the vaccines in stock. If your vets are unsure, please advise them to email [email protected]
for more info. As per the RWAF first alert above, this information will be released in veterinary publications in the coming weeks.
If your rabbit is vaccinated with the Nobivac combi vaccine AND the Cunivak vaccine, they will have been vaccinated against Myxo, RHVD1 and RHVD2. As always, no vaccination is 100% effective and it does not mean your pet will not contract the disease. However, it does mean they have a chance to be treated and survive these normally fatal illnesses.
May 9, 2014
Good news for Australian bunnies!
Apparently, rabbit meat farms in Oz are struggling to cope with the rising costs of vaccinating their livestock. Quite ironic really considering they regularly release the Calicivirus into the wild to ‘control’ wild rabbit populations.
Just 4 rabbit meat farms now remain out of the 80+ that used to be across the country and it would seem that people attitudes to eating the meat is also changing for the better.
A vaccination can be obtained for pet rabbits in some areas of Australia. Calicivirus is known as Rabbit VHD (Viral Haemorrhagic Disease) in the UK. A simple injection once a year will protect UK pet rabbits from both Myxomatosis and VHD.
Read the full article in ABC News, by Alyse Edwards, here: